Electric Literature of 1462-03-9 , The common heterocyclic compound, 1462-03-9, name is 1-Methylcyclopentanol, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[0375] 500 mg (3.87 mmol) of ethyl isocyanatoacetate was dissolved in 5 ml of dichloromethane. 0.05 ml of 4 N hydrochloric acid/1,4-dioxane solution was added to the obtained solution. 465 mg (4.64 mmol) of 1-methylcyclopentanol was added to the resultant mixture, and they were stirred for 3 hours 30 minutes. 10 ml of methanol and 12 ml of 1 N aqueous sodium hydroxide solution were added thereto and they were stirred for 15 minutes. The organic solvent was evaporated under reduced pressure. After extracting with dichloromethane twice, the aqueous layer was neutralized with 1 N aqueous hydrochloric acid solution. The product was extracted with dichloromethane 3 times and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound. The product was subjected to the next reaction without any purification. [0376] Yield: 43.0 mg (0.214 mmol), 5.5% 1H-NMR (CDCl3): (Only the main peaks are shown because the product contained impurities) 1.56 (3H, s), 5.22 (1H, d).
The synthetic route of 1462-03-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AJINOMOTO CO., INC.; US2004/167118; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts