Trinderup, Helle H.; Andersen, Sofie M.; Heuckendorff, Mads; Jensen, Henrik H. published the artcile< How do Various Reaction Parameters Influence Anomeric Selectivity in Chemical Glycosylation with Thioglycosides and NIS/TfOH Activation?>, SDS of cas: 4064-06-6, the main research area is disaccharide preparation stereoselective glycosylation catalyst menthol thioglucopyranoside.
The reaction of glycosyl donor Ph 2,3,4,6-tetra-O-benzyl-1-thio-β-D-glucopyranoside with NIS/TfOH(cat.) was systematically studied under various reaction conditions. Neither the mol. sieve pore size nor amount of NIS activator was found to have an effect on the α/β-ratio in the reaction with L-menthol as glycosyl acceptor. Increasing concentration and the amount of triflic acid catalyst, however was found to increase the β-selectivity in certain cases. Moreover, lowering temperature was found to have a strong effect on the glycosylation outcome.
European Journal of Organic Chemistry published new progress about Disaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.
Referemce:
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Alcohols – Chemistry LibreTexts