Ueno, Masaharu; Kusaka, Ryo; Ohmura, Satoshi D.; Miyoshi, Norikazu published the artcile< Environmentally Benign Ritter Reaction Using Bismuth Salts as a Catalyst>, Computed Properties of 76-84-6, the main research area is Ritter bismuth salt catalyst green.
The authors developed an environmentally benign Ritter reaction of alcs. with nitriles using a com. available bismuth salt as a less harmful catalyst. The detailed reaction profiles revealed that consumption of the ether byproduct as the reaction proceeded was the key for optimizing this reaction, and the yield of the target amide was improved by adding a small amount of water. This finding clearly reveals the significance of using a bismuth salt as the catalyst, as it is not deactivated in the presence of water. This catalyst system has a broad substrate scope, and even with 1 mol-% of the catalyst, the reaction progresses smoothly. It is also possible to react stoichiometric amounts of nitriles and alcs., thus reducing the amount of organic solvent required for the reaction. Furthermore, as the inexpensive bismuth catalyst can be easily removed using aqueous hydrochloric acid, a purification process that only required washing and drying without any organic solvents was successfully established.
European Journal of Organic Chemistry published new progress about Green chemistry. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts