Application of 2215-78-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2215-78-3, name is (4-Phenoxyphenyl)methanol, molecular formula is C13H12O2, molecular weight is 200.2332, as common compound, the synthetic route is as follows.
Under an argon atmosphere and dissolved in the above process resulting in 1 4-phenoxyphenylmethanol (122) (300 mg), DPPA (495 mg) in anhydrous DMF (2.7 mL). DBU the (274 mg) was added under ice cooling,the mixture was stirred for 2 hours, the mixture was further stirred for 24 hours at room temperature. Water was added to the reaction mixture, the reaction mixture was extracted with ethyl acetate (30 mL). The organic layer 2N aqueous hydrochloric acid (30 mL), washed with saturated brine (30 mL), dried over anhydrous sodiumsulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel flash columnchromatography (developing solvent nhexane:ethyl acetate = 50: 1) to give the title compound (103 mg, 30% yield) as acolorless oil.
Statistics shows that 2215-78-3 is playing an increasingly important role. we look forward to future research findings about (4-Phenoxyphenyl)methanol.
Reference:
Patent; Nagoya City University; Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Ida, Shinsuke; Rie, Masaki; (47 pag.)JP5725475; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts