Application of 17100-58-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
Description 10: [2-methyl-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)phenyl]methanol (D10); 4-bromo-2-methyl-benzyl alcohol (D8f, 3Og, 150 mmol), bis(pinacolato)diboron (40 g, 156 mmol), Pd(dppf)CI2(ll) (8 g, 10 mmol), and potassium acetate (44 g, 448 mmol) were dissolved in 1 ,4-dioxane (600 ml_), and the reaction mixture was heated to reflux under N2 for 4 h. After cooling, the reaction mixture was filtered, and the filtrate was concentrated. Purification by column chromatography (silica gel; petroleum ether: ethyl acetate = 5:1 ) afforded the title compound as a red oil (34 g, yield: 90%). 1H NMR (400 MHz, DMSO-c/6) J7.50-7.38 (m, 3H), 5.14 (t, 1 H), 4.51 (d, 2H), 2.22 (s, 3H), 1.28 (s, 12H).
According to the analysis of related databases, 17100-58-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/71504; (2009); A1;,
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