Pamukcu, Rifat; Hanauer, Stephen B.; Chang, Eugene B. published the artcile< Effect of disodium azodisalicylate on electrolyte transport in rabbit ileum and colon in vitro. Comparison with sulfasalazine and 5-aminosalicyclic acid>, Synthetic Route of 6054-98-4, the main research area is azodisalicylate electrolyte transport intestine; diarrhea azodisalicylate.
Azodisalicylate, used to treat ulcerative colitis, causes diarrhea in ≤12.5% of patients. The in vitro effects of azodisalicylate, sulfasalazine, and 5-aminosalicylic acid on rabbit intestinal electrolyte transport were studied. Distal ileal mucosae mounted in Ussing chambers were exposed to varying concentrations of the drugs. Mucosal addition of azodisalicylate (>5 mM) caused the greatest anion-dependent increase in short-circuit current of 83 μA/cm2. Isotope flux measurements suggest that azodisalicylate may stimulate predominantly electrogenic HCO3- secretion and induce net NaCl secretion. In contrast, serosal addition of azodisalicylate and sulfasalazine decreased short-circuit current, and 5-aminosalicylic acid had no effect. Azodisalicylate had no effect on ion transport in distal colon. The effects of azodisalicylate in ileum were not inhibited with piroxicam (an inhibitor of cyclooxygenase). Mucosal cAMP and cGMP levels were unchanged after ileal exposure to azodisalicylate. Azodisalicylate appears to be a mechanistically unusual secretagogue, possibly explaining the increased incidence of diarrhea seen in patients taking the drug.
Gastroenterology published new progress about Colon. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Synthetic Route of 6054-98-4.
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Alcohols – Chemistry LibreTexts