Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H9BrO, blongs to alcohols-buliding-blocks compound. Formula: C9H9BrO
To a solution of 6-bromo-2,3-dihydro-1 H-inden-1 -ol (12 g, 56.3 mmol) in 1 ,4-dioxane (100 mL) was added bis(pinacolato)diboron (18.59 g, 73.2 mmol), potassium acetate (13.82 g, 141 mmol) and the mixture was degassed with argon for 20 mm in a sealed tube. PdCI2(dppf) (2.060 g, 2.82 mmol) was added and the reaction mixture was stirred at 90 00 for 2 h. The reaction mixture was filtered through celite and washed with ethyl acetate. The filtrate wasconcentrated under reduced pressure to afford a crude residue. The crude residue was purified by column chromatography using 20% ethyl acetate in n-hexane as eluent. The eluted fractions were concentrated under reduced pressure to afford the title compound (12 g, 82% yield). 1H NMR (400MHz, ODd3) 5 ppm = 7.88 (s, I H), 7.72 (d, J=7.7 Hz, 1 H), 7.28 (s, 1 H), 5.25 (br t, J=5.8 Hz, 1 H), 3.08 (ddd, J=5.0, 8.4, 16.4 Hz, 1 H), 2.88 – 2.78 (m, 1 H), 2.51 – 2.41 (m, 1 H), 2.01-1.91 (m, 1H), 1.68 (br s, 1H), 1.37-1.27 (m, 12H).
The synthetic route of 75476-86-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; YAN, Hongxing; CALLAHAN, James Francis; HEIGHTMAN, Thomas Daniel; BOEHM, Jeffrey Charles; WOOLFORD, Alison Jo-Anne; (250 pag.)WO2016/203401; (2016); A1;,
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