Furmick, Julie K.;Kaneko, Ichiro;Walsh, Angela N.;Yang, Joanna;Bhogal, Jaskaran S.;Gray, Geoffrey M.;Baso, Juan C.;Browder, Drew O.;Prentice, Jessica L. S.;Montano, Luis A.;Huynh, Chanh C.;Marcus, Lisa M.;Tsosie, Dorian G.;Kwon, Jungeun S.;Quezada, Alexis;Reyes, Nicole M.;Lemming, Brittney;Saini, Puneet;van der Vaart, Arjan;Groy, Thomas L.;Marshall, Pamela A.;Jurutka, Peter W.;Wagner, Carl E. published 《Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)》. The research results were published in《ChemMedChem》 in 2012.Safety of 2,5-Dimethyl-2,5-hexanediol The article conveys some information:
The synthesis of halogenated analogs of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), known commonly as bexarotene, and their evaluation for retinoid X receptor (RXR)-specific agonist performance is described. Compound 1 is FDA approved to treat cutaneous T-cell lymphoma (CTCL); however, bexarotene treatment can induce hypothyroidism and elevated triglyceride levels, presumably by disrupting RXR heterodimer pathways for other nuclear receptors. The novel halogenated analogs in this study were modeled and assessed for their ability to bind to RXR and stimulate RXR homodimerization in an RXRE-mediated transcriptional assay as well as an RXR mammalian-2-hybrid assay. In an array of eight novel compounds, four analogs were discovered to promote RXR-mediated transcription with EC50 values similar to that of 1 and are selective RXR agonists. Our approach also uncovered a periodic trend of increased binding and homodimerization of RXR when substituting a halogen atom for a proton ortho to the carboxylic acid on 1. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Safety of 2,5-Dimethyl-2,5-hexanediol
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