Yan, Yuzhu;Wang, Jihan;Huang, Dageng;Lv, Jing;Li, Hui;An, Jing;Cui, Xiaojian;Zhao, Heping published 《Plasma lipidomics analysis reveals altered lipids signature in patients with osteonecrosis of the femoral head》. The research results were published in《Metabolomics》 in 2022.Category: alcohols-buliding-blocks The article conveys some information:
Although studies have established a link between lipid metabolism disorder and osteonecrosis of the femoral head (ONFH), the characteristics of the circulating lipidome signature of ONFH have not yet been investigated and need to be explored. We aimed to explore the plasma lipidome signatures in patients with ONFH, and to identify specific lipid biomarkers of ONFH. In this study, a comprehensive detection and anal. of plasma lipidomics was conducted in clin. human cohort, including 32 healthy normal control (NC) subjects and 91 ONFH patients in different subgroups [alc.-induced ONFH (AONFH), steroid-induced ONFH (SONFH), and traumatic-induced ONFH (TONFH)] or at different disease stages (stage I, II, III and IV of ONFH) using ultra-high performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS). Overall, the plasma lipidome profile differs between ONFH and NC samples. Lipidome signature including 22 common differentially expressed lipids (DELs) in all three subgroups (variable importance in projection > 1, P < 0.05, fold change > 1.5 or < 0.67, compared to the NC group) was identified. Besides, the subtype-specific lipidome profiles for each ONFH subgroup were also analyzed. Generally, the AONFH subgroup has the largest number of DELs, and the plasma levels of triacylglycerol lipid compounds increased obviously in the AONFH samples. In the subgroup of SONFH, the relative abundance of lipid 4-Aminobenzoic acid increased significantly with changes in the expression of several of its interactive genes. We have identified that 9 stage-pos. and 2 stage-neg. lipids may function as novel biomarkers predicting the progression of ONFH. Our study presents an overview of the phenotype-related plasma lipidome signature of patients with ONFH. The results will provide insight into the mechanisms underlying the metabolism of lipids in the pathogenesis and progression of ONFH and help identify novel lipids biomarkers or disease diagnosis and treatment targets.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.
4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Category: alcohols-buliding-blocks
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts