Electric Literature of 14320-38-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred ice-cooled solution of 3-cyclopentene-1-oi (3.60 rnL, 42.8mrnol) in DCM (80 mL) was added iniidazole, 99-F%, crystalline (6.70 g, 98mmoi) followed by slow addition of tert-butvidimethvisilvi chloride, 1.0 Msolution in dichioroinethane (47.1 mE, 47.1 mrnoi) via a syringe. The resultingmixture was stirred at 0 C for 0.5 h and at ambient temperature overnight (16 h).The reaction was poured into ice water and extracted with DCM (3 X). Thecombined organics were washed with brine (1 X), dried over anhydrous sodiumsulfate and concentrated in vacuo. The crude residue was purified by silica gelchromatography (EtOAc/1-Iexanes. 5 mm at 0 % and 30 mm from 0 to 10 %. 80 g ISCO silica gel column) to give tert-butyl (cy ciopent-3-en- 1 -yloxy)dimethyisiiane in nearly quantitative yield as a colorless liquid, taken directly onto the next step.
According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AMGEN INC.; BROWN, Sean P.; BEDKE, David Karl; DEGRAFFENREID, Michael R.; FU, Jiasheng; LI, Zhihong; GONZALEZ LOPEZ DE TURISO, Felix; GONZALEZ BUENROSTRO, Ana; GRIBBLE, Jr., Michael W.; JOHNSON, Michael G.; KOHN, Todd J.; LI, Kexue; LI, Yunxiao; LIZARZABURU, Mike Elias; REW, Yosup; TAYGERLY, Joshua; WANG, Yingcai; YAN, Xuelei; YU, Ming; ZHU, Jiang; ZANCANELLA, Manuel; JIAO, Xian Yun; ZHU, Liusheng; WANG, Xianghong; MEDINA, Julio C.; DUQUETTE, Jason A.; HOUZE, Jonathan B.; VIMOLRATANA, Marc; CARDOZO, Mario G.; CHENG, Alan C.; (2426 pag.)WO2017/147410; (2017); A1;,
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