HPLC of Formula: 80-46-6In 2016, Kluever, Nils;Vogs, Carolina;Altenburger, Rolf;Escher, Beate I.;Scholz, Stefan published 《Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test》. 《Chemosphere》published the findings. The article contains the following contents:
Fish embryos have become a popular model in ecotoxicol. and toxicol. The fish embryo acute toxicity test (FET) with the zebrafish embryo was recently adopted by the OECD as tech. guideline TG 236 and a large database of concentrations causing 50% lethality (LC50) is available in the literature. Quant. Structure-Activity Relationships (QSARs) of baseline toxicity (also called narcosis) are helpful to estimate the min. toxicity of chems. to be tested and to identify excess toxicity in existing data sets. Here, we analyzed an existing fish embryo toxicity database and established a QSAR for fish embryo LC50 using chems. that were independently classified to act according to the non-specific mode of action of baseline toxicity. The octanol-water partition coefficient Kow is commonly applied to discriminate between non-polar and polar narcotics. Replacing the Kow by the liposome-water partition coefficient Klipw yielded a common QSAR for polar and non-polar baseline toxicants. This developed baseline toxicity QSAR was applied to compare the final mode of action (MOA) assignment of 132 chems. Further, we included the anal. of internal lethal concentration (ILC50) and chem. activity (La50) as complementary approaches to evaluate the robustness of the FET baseline toxicity. The anal. of the FET dataset revealed that specifically acting and reactive chems. converged towards the baseline toxicity QSAR with increasing hydrophobicity. The developed FET baseline toxicity QSAR can be used to identify specifically acting or reactive compounds by determination of the toxic ratio and in combination with appropriate endpoints to infer the MOA for chems. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .
4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. HPLC of Formula: 80-46-6
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts