Category: alcohols-buliding-blocksIn 2016, Sotto, Nicolas;Cazorla, Clement;Villette, Carole;Billamboz, Muriel;Len, Christophe published 《Selective Pinacol-Coupling Reaction using a Continuous Flow System》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:
The first continuous flow pinacol coupling reaction of carbonyl compounds was successfully achieved within only 2 min during a single pass through a cartridge filled with zinc(0). The optimized method allowed the efficient production of gram-scale value-added compounds with high productivity. The developed methodol. is efficient for aromatic or α,β-unsaturated aldehydes but gives moderate results for more stable acetophenone derivatives Moreover, the flow method displayed better results in terms of yield and selectivity in comparison to the corresponding batch methodol. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .
Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Category: alcohols-buliding-blocks) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.
Reference:
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