Reference of 4-(2-Phenylpropan-2-yl)phenolIn 2019, Tanaka, Kumpei;Gotoh, Hiroaki published 《Development of the radical C-O coupling reaction of phenols toward the synthesis of natural products comprising a diaryl ether skeleton》. 《Tetrahedron》published the findings. The article contains the following contents:
Compounds comprising a diaryl ether skeleton exist among natural phenols. The diaryl ether skeleton is thought to be biosynthesized through the coupling of two or more phenols. It is an important structural feature in medicines and agrochems., and it is imperative to develop methods for constructing such skeletons in organic synthesis. However, by the synthesis method through the coupling of phenols, coupling occurs preferentially at the ortho-substituted carbon atom of phenols. In this study, various radical-generating reagents and conditions were investigated with the aim of developing a short-step construction method of the diaryl ether skeleton by the radical homo-coupling of two phenol mols. In addition, cross-coupling reactions between radicals of 2,4,6-tri-tert-butylphenol and p-substituted phenol were conducted to synthesize eight C (ortho)-O coupling products. Based on the results, a computational chem. approach was employed to verify the cause of C (ortho)-O bond formation. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.
4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Reference of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.
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