Reference of 445-26-1 ,Some common heterocyclic compound, 445-26-1, molecular formula is C8H9FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Add 0.5 mmol of 1-phenylethanol to the test tube.Add 1.5 mmol of dipropylene glycol dimethyl ether to the oxygen balloon.Reaction at 120 C for 12 hours,By gas chromatography, the reaction was complete,To the reaction system, sodium formate 2.5 mmol was added.Add 0.0025 mmol of Catalyst B and add 4 mL of methanol:water (3:1).Nitrogen replacement 3 times, 50 C reaction 12h, after the end of the reaction, washed with water,The aqueous phase was extracted three times with ethyl acetate.Column chromatography separation (petroleum ether: ethyl acetate = 10:1),(S)-1-ethanol (57.3 mg) was obtained in a yield of 93%.The ee value is 95%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,445-26-1, its application will become more common.
Reference:
Patent; China Three Gorges University; Zhou Haifeng; Cui Peng; Chen Yongsheng; Liu Qixing; (12 pag.)CN110002961; (2019); A;,
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