Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 75476-86-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 75476-86-7
A suspension of 6-bromoindan-1-ol (240 mg, 1.1 mmol), potassium acetate (550 mg, 5.6 mmol) and 4,4,5,5,4′,4′,5′,5′-octamethyl-[2,2′]bi[[1,3,2]dioxaborolanyl](430 mg, 1.7 mmol) in 1,4-doxane (3.3 mL) was first degassed with stream of nitrogen for ?5 min, then [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1:1) (92 mg, 0.11 mmol) was added and the mixture was heated to 90 C. overnight. The reaction mixture was then diluted with EtOAc, filtered through celite, and concentrated. The residue was purified by flash chromatography on a silica gel column eluting with 0 to 25% EtOAc/hexanes to provide the desired product (256 mg, 87%). LC-MS calculated for C15H20BO2 (M+H-H2O)+: m/z=243.2. found 243.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Incyte Corporation; Wu, Liangxing; Courter, Joel R.; He, Chunhong; Li, Jingwei; Lu, Liang; Sun, Yaping; Wang, Xiaozhao; Yao, Wenqing; Zhang, Colin; Zhuo, Jincong; (87 pag.)US2016/9720; (2016); A1;,
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