Islam, Rafiquel;Melvin, Steven D.;Kit Yu, Richard Man;O’Connor, Wayne A.;Anh Tran, Thi Kim;Andrew-Priestley, Megan;Leusch, Frederic D. L.;MacFarlane, Geoff R. published 《Estrogenic mixtures induce alterations in lipidomic profiles in the gonads of female oysters》. The research results were published in《Chemosphere》 in 2022.Computed Properties of C14H22O The article conveys some information:
This study aimed to reveal possible alterations to lipidomic profiles in Sydney rock oysters, Saccostrea glomerata, exposed to estrogenic mixtures (i.e., estrone, E1; 17β-estradiol, E2; estriol, E3; 17α-ethinylestradiol, EE2; bisphenol A, BPA; 4-t-octylphenol, 4-t-OP; and 4-nonylphenol, 4-NP) at “low” and “high” concentrations, typical of those detected in Australian and global receiving waters. A seven-day acute exposure window exhibited significantly lower abundances of many non-polar metabolites in digestive gland, gills, and gonads. Overall, there was a strong effect of the carrier solvent ethanol (despite a low exposure of 0.0002%), with all solvent containing treatments exhibiting lower abundances of lipidic metabolites, especially in the gill and digestive gland. No significant changes of the lipidome were exhibited in the male gonad by estrogenic exposure. However, in the female gonad, significant reductions of phospholipids and phosphatidylcholine were associated with exposure to high estrogenic mixtures We hypothesise that the decreases in these phospholipids in the female gonad may be attributable to (1) lower algal consumption and thus lower uptake of lipidic building blocks; (2) a reduction of available substrates for phospholipid and phosphatidylcholine synthesis; and/or (3) induction of reactive oxygen species via estrogen metabolism, which may cause lipid peroxidation and lower abundance of phospholipids. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .
4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Computed Properties of C14H22O
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