Goeminne, Pieter C.;Vandendriessche, Thomas;Van Eldere, Johan;Nicolai, Bart M.;Hertog, Maarten L. A. T. M.;Dupont, Lieven J. published 《Detection of Pseudomonas aeruginosa in sputum headspace through volatile organic compound analysis》 in 2012. The article was appeared in 《Respiratory Research》. They have made some progress in their research.SDS of cas: 110-03-2 The article mentions the following:
Introduction: Chronic pulmonary infection is the hallmark of Cystic Fibrosis lung disease. Searching for faster and easier screening may lead to faster diagnosis and treatment of Pseudomonas aeruginosa (P. aeruginosa). Our aim was to analyze and build a model to predict the presence of P. aeruginosa in sputa. Methods: Sputa from 28 bronchiectatic patients were used for bacterial culturing and anal. of volatile compounds by gas chromatog.-mass spectrometry. Data anal. and model building were done by Partial Least Squares Regression Discriminant anal. (PLS-DA). Two anal. were performed: one comparing P. aeruginosa pos. with neg. cultures at study visit (PA model) and one comparing chronic colonization according to the Leeds criteria with P. aeruginosa neg. patients (PACC model). Results: The PA model prediction of P. aeruginosa presence was rather poor, with a high number of false positives and false negatives. On the other hand, the PACC model was stable and explained chronic P. aeruginosa presence for 95% with 4 PLS-DA factors, with a sensitivity of 100%, a pos. predictive value of 86% and a neg. predictive value of 100%. Conclusion: Our study shows the potential for building a prediction model for the presence of chronic P. aeruginosa based on volatiles from sputum. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.SDS of cas: 110-03-2
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