Wu, Shaofeng;Geng, Furong;Dong, Jianyu;Liu, Long;Zhou, Yongbo published 《Metal-Free Oxidative Annulation of Phenols and Amines: A General Synthesis of Benzoxazoles》 in 2022. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Recommanded Product: 4-(2-Phenylpropan-2-yl)phenol The article mentions the following:
Under metal-free conditions, a highly general synthesis of benzoxazoles I [R = 5-i-Pr, 5,7-di-ter-Bu, 6-Ph, etc.; R1 = n-Pr, t-Bu, Ph, etc.] direct from abundant and easily available phenols and amines was developed via a modular phenol functionalization controlled by TEMPO. In the reaction, various phenols and primary amines with a broad range of functional groups were compatible, producing structurally and functionally diverse benzoxazoles I without or with trace observation of the byproducts of phenol transformation with amines. The practical synthesis, especially for drug tafamidis, demonstrated decisive advantages in generality, selectivity, efficiency, and atom- and step-economies over traditional methods, even in the cases of low yields. Mechanistically, the radical adducts of TEMPO with ortho-cyclohexa-2,4-dien-1-one radicals rather than the well-recognized cyclohexa-3,5-diene-1,2-diones might serve as intermediates. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.
4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Recommanded Product: 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts