Synthetic Route of 7250-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7250-55-7, name is Dimethyl 3-hydroxypentanedioate, molecular formula is C7H12O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of dimethyl 3-hydroxypentanedioate (20 g, 114 mmol) in CH2CI2 (100 mL) was added lH-imidazole (15.46 g, 227 mmol) and TBDPSC1 (46.8 g, 170 mmol) at 25C. The solution was stirred at 25C for 3 h, and the mixture was filtrated and the filter cake was washed by CH2CI2 (100 mL). The filtrate was concentrated in vacuo to afford the crude product, which was purified by gradient elution on S1O2 (ISCO, 120 g RediSep Gold column, 0 to 10% EtO Ac/Pet. ether over 90 min, dry-loaded) to afford the title compound. LRMS (M+H)+: 437.2.
According to the analysis of related databases, 7250-55-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; EMBREY, Mark, W.; HARTINGH, Timothy John; LABROLI, Marc; RAHEEM, Izzat, T.; (75 pag.)WO2019/160783; (2019); A1;,
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