Yamashita, Junko;Hirata, Yukio published 《Running fits and γ-aminobutyric acid of the superior colliculus of the mouse》 in 1979. The article was appeared in 《Journal of Nutritional Science and Vitaminology》. They have made some progress in their research.Electric Literature of C8H12ClNO2 The article mentions the following:
The γ-aminobutyric acid content of the superior colliculus of the mouse brain was decreased following the induction of running fits by the intracollicular injection of the antivitamin B6 compound semicarbazide. Aminooxyacetic acid hemihydrochloride, an inhibitor of 4-aminobutyrate-2-oxoglutarate aminotransferase (EC 2.6.1.19) with a resultant increase in GABA levels, has been shown to exert an antidotal effect on the induction of running fits. Therefore, this type of convulsive behavior is apparently associated with diminished levels of GABA in the superior colliculus. Running fits were also induced by the antivitamin B6 compounds thiosemicarbazide and 4-deoxypyridoxine-HCl, and presumedly this was also the result of a decrease in GABA level. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.
5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Electric Literature of C8H12ClNO2) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.
Reference:
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