Leblanc, Virginie;Yokota, Mariko;Grandidier, Marie-Helene;Yoshida, Daisuke;Adriaens, Els;Cotovio, Jose;Kyoutani, Daiki;Alepee, Nathalie published 《SkinEthic HCE Eye Irritation Test: Similar performance demonstrated after long distance shipment and extended storage conditions》. The research results were published in《Toxicology In Vitro》 in 2019.Electric Literature of C8H18O2 The article conveys some information:
Assessment of ocular irritation risk is an international regulatory requirement in the safety evaluation of products. In response to this need, L’Oreal developed the SkinEthic Human Corneal Epithelium (HCE) Eye Irritation Test (EIT) that has been included in OECD Test Guideline 492. SkinEthic HCE EIT is able to correctly and reliably identify chems. not requiring classification vs. labeling for eye irritation or serious eye damage according to UN GHS. In an effort to promote its global use, the performance of the method was evaluated after long-distance shipment and compared to European shipment conditions. Results obtained by Cosmos Tech. Center (Japan) after extended tissues transit were compared to results obtained in L’Oreál (France). Thirty-nine out of 40 blinded chems., representing different functional chem. classes, were consistently classified in both laboratories The SkinEthic HCE EIT test method was also evaluated for its performance after extended storage of the tissues. The performance was in agreement with the values reported in OECD TG 492, with an overall accuracy of 87.1% (based on 119 chems.), sensitivity of 95.5% and specificity of 73.5%. The reliability and relevance of SkinEthic HCE EIT test method after long-distance shipment and extended storage remain in agreement with regulatory validation criteria. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Electric Literature of C8H18O2
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