Explore more uses of cas: 80-46-6 | Bioorganic & Medicinal Chemistry Letters

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Quality Control of 4-tert-Amylphenol

Lazewska, Dorota;Olejarz-Maciej, Agnieszka;Kaleta, Maria;Bajda, Marek;Siwek, Agata;Karcz, Tadeusz;Doroz-Plonka, Agata;Cichon, Urszula;Kuder, Kamil;Kiec-Kononowicz, Katarzyna published 《4-tert-Pentylphenoxyalkyl derivatives – Histamine H3 receptor ligands and monoamine oxidase B inhibitors》 in 2018. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Quality Control of 4-tert-Amylphenol The article mentions the following:

The synthesis and biol. activity of 4-tert-pentylphenoxypropyl derivatives I (m = 1, 2, 3, etc.; n = 1; R = H, 2-CH3, 2,6-(CH3)2, 3,5-(CH3)2, etc.) are described in this manuscript. All compounds (except one) showed human histamine H3 receptor affinity with Ki values below 760 nM. The inhibitory activity towards human monoamine oxidase B (hMAO B) was evaluated using a fluorometric Amplex-Red assay, and most of the compounds were found to be effective in the submicromolar range. Among them, 1-(3-(4-tert-pentylphenoxy)propyl)pyrrolidine I (m = 1; n = 1; R = H) exhibited hMAO B inhibitory activity with an IC50 value of 4.5 nM. In addition, hMAO B inhibition by I (m = 1; n = 1; R = H) was shown to be non-competitive and reversible. Further, recently described potent histamine H3 receptor ligands – 4-tert-pentylphenoxyalkyl derivatives (with a 4-8 carbon spacer) – were evaluated for hMAO B inhibitory activity, and some of them displayed activity in the submicromolar range. Selected compounds were also tested for human MAO A (hMAO A) inhibitory potencies and exhibited no activity. Moreover, mol. modeling studies were carried out for tested compounds to explain their mol. mechanism of hMAO B inhibition and the selectivity of compounds for hMAO B over hMAO A. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Quality Control of 4-tert-Amylphenol

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