Computed Properties of C8H18O2In 2013, Kojima, Hajime;Hayashi, Kazuhiko;Sakaguchi, Hitoshi;Omori, Takashi;Otoizumi, Takuya;Sozu, Takashi;Kuwahara, Hirofumi;Hayashi, Takumi;Sakaguchi, Mayumi;Toyoda, Akemi;Goto, Haruka;Watanabe, Shinichi;Ahiko, Kyoko;Nakamura, Tsuneaki;Morimoto, Takashi published 《Second-phase validation study of short time exposure test for assessment of eye irritation potency of chemicals》. 《Toxicology In Vitro》published the findings. The article contains the following contents:
A Short Time Exposure (STE) test is a cytotoxicity test that uses SIRC cells (rabbit corneal cell line) to assess eye irritation potency following a 5-min chem. exposure. This second-phase validation study assessed the predictive capacity of the STE test using 40 coded test substances at three laboratories A Validation Management Team (VMT) then evaluated the predictivity of the STE test for United Nation (UN) Globally Harmonized System (GHS) categories using 63 test substances including the results of the first-phase validation study. The STE test can assess not only the severe or corrosive ocular irritants (corresponding to the UN GHS Category 1) but also non-irritant (corresponding to UN GHS Non Category) from other toxicity classes, especially for limited types of test substances. The predictivity by STE test, however, was insufficient for identification of UN GHS categories (Category 1, Category 2, or Non Category). These results suggest that the STE test can be recommended as an initial step in a top-down approach to identification of severe irritants and test substances that require classification for eye irritation (UN GHS Category 1) as well as an initial step in a bottom-up approach to identification of test substances that do not require classification for eye irritation (UN GHS Non Category) from other toxicity classes, especially for limited types of test substances. The STE test is not considered adequate for the identification of mild or moderate irritants (i.e., UN GHS Categories 2A and 2B) and severe irritants (UN GHS Category 1).2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Computed Properties of C8H18O2
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