Stock, Christian;Brueckner, Reinhard published 《Mild and High-Yielding Molybdenum(VI) Dichloride Dioxide-Catalyzed Formation of Mono-, Di-, Tri-, and Tetracarbamates from Alcohols and Aromatic or Aliphatic Isocyanates》. The research results were published in《Advanced Synthesis & Catalysis》 in 2012.Synthetic Route of C8H18O2 The article conveys some information:
Both molybdenum(VI) dichloride dioxide (MoO2Cl2) and its DMF (DMF) complex catalyze the addition of alcs. to isocyanates giving carbamates. Most additions proceed to completion at room temperature within 20 min using as little as 0.1 mol% of the catalyst when working on a 1-mmol scale or just 100 ppm working on a 20-mmol scale. Sterically encumbered substrates reacted to completion when 1 mol% of the catalyst was employed. Diols, triols, and tetraols reacted with monoisocyanates likewise, as did monofunctional alcs. and diisocyanates. These pairings furnished di-, tri-, tetra-, and dicarbamates, resp. Reactants, which were poorly soluble in CH2Cl2 at room temperature required elevating the temperature and possibly choosing a higher-boiling solvent (ClCH2CH2Cl, DMF) as well. Additions of diols to diisocyanates were feasible, too, giving polycarbamates as we presume.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Synthetic Route of C8H18O2
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts