Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol《Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions》 was published in 2016. The authors were Mandai, Hiroki;Fujii, Kazuki;Yasuhara, Hiroshi;Abe, Kenko;Mitsudo, Koichi;Korenaga, Toshinobu;Suga, Seiji, and the article was included in《Nature Communications》. The author mentioned the following in the article:
It was demonstrated that by attaching a binaphthyl moiety, appropriately modified to establish H-bonding interactions within the key intermediates in the catalytic cycle and a 4-aminopyridyl unit, exceptionally efficient organic mols. could be prepared that facilitated enantioselective acyl transfer reactions. As little as 0.5 mol% of a member of the new catalyst class was sufficient to generate acyl-substituted all-carbon quaternary stereogenic centers in quant. yield and in up to 98:2 enantiomeric ratio (er) in 5 h. Kinetic resolution or desymmetrization of 1,2-diol could be performed with high efficiency and enantioselectivity as well.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.
Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Safety of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.
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