Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4461-39-6, name is N-(2-Hydroxyethyl)-1,3-propanediamine. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks
To a round-bottom flask (250 mL) containing 3-(benzyloxy)benzaldehyde (3.50 g, 16.5 mmol) dissolved in methanol (100 ml), N-(2-Hydroxyethyl)-1,3-propanediamine (3.50 g, 16.5 mmol) was added. The resulting mixture was stirred for 2 h at ambient temperature. Then carbon disulfide (1.00 mL, 16.5 mmol) was slowly mixed to the reaction, which was kept under stirring for about 40 min. Cu(O2CCH3)2H2O (1.50 g, 8.25 mmol) was then added and a brown solid was formed. After stirring for 4 h, the formed brown precipitate was filtrated and re-crystallized in a 4:1 mixture of CH2Cl2 and toluene. Yield 81%. Mp. 93.6-95.0 C. IR (cm-1, KBr): 1496 (nuN-CS); 980 {nuasym(C-S)}; 601 {nusym(C-S)}. Analysis of C, H and N, respectively for C40H48N4O4S4Cu found% (calc.%): 56.95 (57.15); 5.67 (5.76); 6.58 (6.66).
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Reference:
Article; Ferreira, Isabella P.; Lima, Geraldo M. De; Paniago, Eucler B.; Takahashi, Jacqueline A.; Krambrock, Klaus; Pinheiro, Carlos B.; Wardell, James L.; Visentin, Lorenzo C.; Journal of Molecular Structure; vol. 1048; (2013); p. 357 – 366;,
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