Heiger-Bernays, Wendy J.;Wegner, Susanna;Dix, David J. published 《High-throughput in Vitro Data To Inform Prioritization of Ambient Water Monitoring and Testing for Endocrine Active Chemicals》. The research results were published in《Environmental Science & Technology》 in 2018.Quality Control of 4-tert-Amylphenol The article conveys some information:
The presence of industrial chems., consumer product chems., and pharmaceuticals is well documented in waters in the US and globally. Most of these chems. lack health-protective guidelines and many have been shown to have endocrine bioactivity. There is currently no systematic or national prioritization for monitoring waters for chems. with endocrine disrupting activity. The authors propose Ambient Water Bioactivity Concentrations (AWBCs) generated from high throughput data as a health-based screen for endocrine bioactivity of chems. in water. The US EPA ToxCast program has screened over 1800 chems. for estrogen receptor (ER) and androgen receptor (AR) pathway bioactivity. AWBCs are were calculated for 110 ER and 212 AR bioactive chems. using high throughput ToxCast data from in vitro screening assays and predictive pathway models, high-throughput toxicokinetic data, and data-driven assumptions about consumption of water. Chem.-specific AWBCs are compared with measured water concentrations in datasets from the greater Denver area, Minnesota lakes, and Oregon waters, demonstrating a framework for identifying endocrine bioactive chems. This approach can be used to screen potential cumulative endocrine activity in drinking water and to inform prioritization of future monitoring, chem. testing and pollution prevention efforts. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.
4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Quality Control of 4-tert-Amylphenol
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts