Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 16545-68-9, formula is C3H6O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Name: Cyclopropanol
Freeman-Cook, Kevin D.;Hoffman, Robert L.;Behenna, Douglas C.;Boras, Britton;Carelli, Jordan;Diehl, Wade;Ferre, Rose Ann;He, You-Ai;Hui, Andrea;Huang, Buwen;Huser, Nanni;Jones, Rhys;Kephart, Susan E.;Lapek, John;McTigue, Michele;Miller, Nichol;Murray, Brion W.;Nagata, Asako;Nguyen, Lisa;Niessen, Sherry;Ninkovic, Sacha;O′Doherty, Inish;Ornelas, Martha A.;Solowiej, James;Sutton, Scott C.;Tran, Khanh;Tseng, Elaine;Visswanathan, Ravi;Xu, Meirong;Zehnder, Luke;Zhang, Qin;Zhang, Cathy;Dann, Stephen research published 《 Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer》, the research content is summarized as follows. Control of the cell cycle through selective pharmacol. inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level of control to addnl. cell cycle CDK isoforms represents an opportunity to expand to addnl. tumor types and potentially provide benefits to patients that develop tumors resistant to selective CDK4/6 inhibitors. However, broad-spectrum CDK inhibitors have a long history of failure due to safety concerns. In this approach, we describe the use of structure-based drug design and Free-Wilson anal. to optimize a series of CDK2/4/6 inhibitors. Further, we detail the use of mol. dynamics simulations to provide insights into the basis for selectivity against CDK9. Based on overall potency, selectivity, and ADME profile, PF-06873600 (22) was identified as a candidate for the treatment of cancer and advanced to phase 1 clin. trials.
Name: Cyclopropanol, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts