In general, the hydroxyl group makes alcohols polar. 16545-68-9, formula is C3H6O, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Application of C3H6O
Chen, Tao;Reich, Nicholas William;Bell, Noah;Finn, Patricia D.;Rodriguez, David;Kohler, Jill;Kozuka, Kenji;He, Limin;Spencer, Andrew G.;Charmot, Dominique;Navre, Marc;Carreras, Christopher W.;Koo-McCoy, Samantha;Tabora, Jocelyn;Caldwell, Jeremy S.;Jacobs, Jeffrey W.;Lewis, Jason Gustaf research published 《 Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)》, the research content is summarized as follows. Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) is one of the major effectors in bile acid sensing, with demonstrated influence on metabolic, inflammatory and proliferative processes. The pharmacol. utility of TGR5 agonists has been limited by systemic target-related effects such as excessive gallbladder filling and blockade of gallbladder emptying. Gut-restricted TGR5 agonists, however, have the potential to avoid these side effects and consequently be developed into drugs with acceptable safety profiles. The authors describe the discovery and optimization of a series of gut-restricted TGR5 agonists that elicit a potent response in mice, with minimal gallbladder-related effects. The series includes 12 (4-(2,5-Dichloro-4-{[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl}-phenoxymethyl)-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-benzamide) (TGR5 EC50: human, 143 nM; mouse, 1.2 nM), a compound with minimal systemic availability that may have therapeutic value to patients with type 2 diabetes mellitus, non-alc. steatohepatitis or inflammatory bowel disease.
Application of C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts