Adding a certain compound to certain chemical reactions, such as: 2807-30-9, 2-Propoxyethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2807-30-9, blongs to alcohols-buliding-blocks compound. Formula: C5H12O2
Dimethyl 4-nitro-1H-pyrazole-3, 5-dicarboxylate (WO00/24745, page 48, preparation 2) (15g, 60mmol), 2-propoxyethanol (8.2mL,70mmol) and triphenylphosphine(18. 9g,70mmol) were dissolved in tetrahydrofuran(150mL) and the solution cooled to0 C. The solution was treated withdiisopropyl azodicarboxylate (14.2mL,70mmol) and the reaction mixture stirred at0 C for 3 hours before being allowed to warm to room temperature. The reaction mixture was concentrated in vacuo and the residue purified by column chromatography on silica gel eluting with ethyl acetate: pentane 15: 85 and then againeluting withdichloromethane to yield the title product. ‘H NMR (CD30D, 400MHz) a : 0.82 (t, 3H), 1.47 (q, 2H), 3.34 (t, 2H), 3.78 (t, 2H), 3.91 (s, 6H), 4.76 (t, 2H). MS APCI+ m/z 316 [MH] +
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/49616; (2005); A1;,
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