With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.HPLC of Formula: C17H16O3
The more polar product of Example 1, Step 4 (2,10-bistrifluoromethyl-7,7-dimethyl-5-hydroxy-7H-benzo[C]fluorene,2.6 grams), 1,1-bis-(4-methoxyphenyl)-2-propyn-1-ol (2.26 grams), 14 drops of methane sulfonic acid and 250mL of methylene chloride were combined in a reaction flask and stirred overnight under a nitrogen atmosphere. Thereaction mixture was washed carefully with a mixture of 250 mL of a saturated sodium bicarbonate solution and 250 mLof water. The organic layer was separated, dried over sodium sulfate, and concentrated by rotary evaporation to get abrown solid. This brown solid was purified via flash column chromatography on a silica gel column using a mixture ofhexane and ethyl acetate (80/20) as the eluant to yield 1.5 grams of an off white solid. A NMR spectrum showed theproduct to have a structure consistent with 3,3-bis-(4-methoxyphenyl)-7,10-bistrifluoromethyl-13,13-dimethyl-3H,13Hindeno[2.1-f]naphtho[1,2-b]pyran as represented by the following graphic formula
At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; TRANSITIONS OPTICAL INCORPORATED; CHOPRA, ENU; (24 pag.)KR101593284; (2016); B1;,
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