Synthetic Route of 2807-30-9 ,Some common heterocyclic compound, 2807-30-9, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Examples 3 to 14 – synthesis of 2-amino-4-substituted-6-(4-fluorophenyl)-pyrido(3,2-d) pyrimidinesTo a solution of the 2-amino-4-thiomethyl-6-(4-fluorophenyl)-pyrido(3,2- d)pyrimidine of example 2 (56 mg) in a suitable alcohol (5 ml) was added a 2 M solution of lithium diisopropylamide (LDA) in tetrahydrofuran (1 ml). The reaction mixture was stirred at room temperature for 3 days. The excess alcohol was evaporated in vacuo and the crude residue was purified by preparative thin layer chromatography on silica using a mixture of toluene and acetonitrile as the mobile phase (in a volume ratio of 1 :1 ). If necessary a second purification was performed by HPLC on a C18-RP column (100 x30mm Gemini 5 mum) with a gradient of H2O, 0.05% TEA-acetonitrile. The resulting compounds were isolated in yields varying from 30 to 50%, depending on the alcohol used, and were characterized by their mass spectra MS as indicated below.2-amino-4-(2-propoxyethoxy)-6-(4-fluorophenyl)pyrido(3,2-d)pyrimidine (example 3) was obtained from 2-propoxyethanol; MS (m/z) : 343 ([M+H]+, 100).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.
Reference:
Patent; GILEAD SCIENCES, INC.; WO2008/77650; (2008); A1;,
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