With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 141699-55-0, formula is C8H15NO3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Safety of tert-Butyl 3-hydroxyazetidine-1-carboxylate
Barlaam, Bernard;Boiko, Scott;Boyd, Scott;Dry, Hannah;Gingipalli, Lakshmaiah;Ikeda, Timothy;Johnson, Tony;Kawatkar, Sameer;Lorthioir, Olivier;Pike, Andy;Pollard, Hannah;Read, Jon;Su, Qibin;Wang, Haiyun;Wang, Huimin;Wang, Lianghe;Wang, Peng;Edmondson, Scott D. research published 《 Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors》, the research content is summarized as follows. Hybridization of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimization of a novel pyrimidine-based series of potent and selective SYK inhibitors, where the original aminomethylene group was replaced by a 3,4-diaminotetrahydropyran group. The initial compound 5 achieved excellent SYK potency. However, it suffered from poor permeability and modest kinase selectivity. Further modifications of the 3,4-diaminotetrahydropyran group were identified and the interactions of those groups with Asp512 were characterised by protein X-ray crystallog. Further optimization of this series saw mixed results where permeability and kinase selectivity were increased and oral bioavailability was achieved in the series, but at the expense of potent hERG inhibition.
Safety of tert-Butyl 3-hydroxyazetidine-1-carboxylate, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.
Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts