Electric Literature of 16308-92-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16308-92-2 as follows.
(2,4-dimethylphenyl)methanol (1.72 g, 12.7 mmol) and triethyl amine (5.1 mL, 38.1 mmol) were dissolved in dichloromethane (50 mL) and the solution was cooled to 0C. A solution of methanesulfonyl chloride (1.18 mL, 15.2 mmol) in dichloromethane (20 mL)was added dropwise for a period of 20 minutes. The reaction mixture was thereafter allowed to reach room temperature, and was stirred at that temperature for 2 hours. The excess of methanesulfonyl chloride wasquenched by addition of methanol (5.0 mL) and stirring for an additional 10 minutes. The reaction mixture was extracted with dilute HC1 (5%, 100 mL), and thereafter washed with sodium bicarbonate (5% solution, 2×50 mL) and with brine (2×100 mL). The dichloromethane phased was dried over anhydrous sodium sulfate and evaporated to dryness,yielding 2.57 g of the title product, which was used without further purification in the subsequent step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16308-92-2, its application will become more common.
Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; MALMSTROeM, Lars Jonas; LARSSON, Johanna Maria; (212 pag.)WO2017/9651; (2017); A1;,
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