Introduction of a new synthetic route about 23002-78-0

Although many compounds look similar to this compound(23002-78-0)Synthetic Route of C6H7NOS, numerous studies have shown that this compound(SMILES:CC(C1=CSC(C)=N1)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(2-Methylthiazol-4-yl)ethanone(SMILESS: CC(C1=CSC(C)=N1)=O,cas:23002-78-0) is researched.Application of 4221-99-2. The article 《Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:23002-78-0).

Structure-based design, synthesis, and biol. evaluation of a series of 2-amino-3,4-dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. One inhibitor showed potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays. The model of this compound suggested possible interactions in the active site.

Although many compounds look similar to this compound(23002-78-0)Synthetic Route of C6H7NOS, numerous studies have shown that this compound(SMILES:CC(C1=CSC(C)=N1)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts