Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Platinum(II) complexes containing hydrazide-based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents.Application of 12080-32-9.
Four new N,N-bis(diphenylphosphino)amine ligands (amine = 1-amino-4-methylpiperazine (L1), N-aminophthalimide (L2), 4-aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using IR and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single-crystal x-ray diffraction techniques. The antitumor activities of the synthesized complexes determined using MTT assay on MDA-MB-231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose- and time-dependent manner (e.g. at a complex concentration of 100 μg ml-1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1-C4, resp.). Theor. approaches were also used to investigate the energy and the nature of metal-ligand and metal-chlorine interactions in the complexes, which could explain their biol. activities. The interaction between ligand and Pt is stronger in C2, while the Pt-Cl interaction is weaker in this complex in comparison with the other complexes.
When you point to this article, it is believed that you are also very interested in this compound(12080-32-9)Application of 12080-32-9 and due to space limitations, I can only present the most important information.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts