HPLC of Formula: 16588-26-4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Author is Thakur, Vinay V.; Kim, Joseph T.; Hamilton, Andrew D.; Bailey, Christopher M.; Domaoal, Robert A.; Wang, Ligong; Anderson, Karen S.; Jorgensen, William L..
Non-nucleoside inhibitors of HIV-1 reverse transcriptase are being pursued through synthesis and assaying for anti-viral activity. Following computational analyses, the focus has been on the motif Het-NH-Ph-U, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Previous investigations with Het = 2-thiazoyl and 2-pyrimidinyl are extended here to triazinyl derivatives The result is several NNRTIs in the 2-20 nM range with negligible cytotoxicity and auspicious predicted pharmacol. properties.
In addition to the literature in the link below, there is a lot of literature about this compound(3-Bromo-4-chloronitrobenzene)HPLC of Formula: 16588-26-4, illustrating the importance and wide applicability of this compound(16588-26-4).
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