Ghosh, Arun K.; Pandey, Satyendra; Gangarajula, Sudhakar; Kulkarni, Sarang; Xu, Xiaoming; Rao, Kalapala Venkateswara; Huang, Xiangping; Tang, Jordan published an article about the compound: 1-(2-Methylthiazol-4-yl)ethanone( cas:23002-78-0,SMILESS:CC(C1=CSC(C)=N1)=O ).SDS of cas: 23002-78-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23002-78-0) through the article.
Structure-based design, synthesis, and biol. evaluation of a series of 2-amino-3,4-dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. One inhibitor showed potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays. The model of this compound suggested possible interactions in the active site.
In addition to the literature in the link below, there is a lot of literature about this compound(1-(2-Methylthiazol-4-yl)ethanone)SDS of cas: 23002-78-0, illustrating the importance and wide applicability of this compound(23002-78-0).
Reference:
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