Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, Article, Chemical Communications (Cambridge, United Kingdom) called Interception of amide ylides with sulfonamides: synthesis of (E)-N-sulfonyl amidines catalyzed by Zn(OTf)2, Author is Chen, Jijun; Long, Wenhao; Fang, Shangwen; Yang, Yonggang; Wan, Xiaobing, the main research direction is sulfonyl amidine preparation diastereoselective crystal structure mol; sulfonamide amide intermol condensation zinc catalyst.Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.
An efficient method was reported for the synthesis of (E)-N-sulfonyl amidines such as I [R1 = H, Me, Ph, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Me, i-Pr, Ph, etc.; R1R3 = (CH2)2, (CH2)3; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2, etc.; R4 = Ph, 4-MeC6H4, 2-naphthyl, etc.] in good yields with excellent stereoselectivity via Zn-catalyzed intermol. condensation reaction between sulfonamides and various amides. The wide substrate scope, exceptional functional group tolerance, operational simplicity and neutral reaction conditions made this mechanistically novel method well suited for preparing amidine compounds I.
In addition to the literature in the link below, there is a lot of literature about this compound(1-(4-Chlorophenyl)pyrrolidin-2-one)Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one, illustrating the importance and wide applicability of this compound(7661-33-8).
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