The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ) is researched.Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.Prince, Robin J.; Gao, Fang; Pazienza, Jessica E.; Marx, Isaac E.; Schulz, Jurgen; Hopkins, Brian T. published the article 《Utilization of Cyclic Amides as Masked Aldehyde Equivalents in Reductive Amination Reactions》 about this compound( cas:7661-33-8 ) in Journal of Organic Chemistry. Keywords: cyclic amide masked aldehyde equivalent reductive amination. Let’s learn more about this compound (cas:7661-33-8).
An operationally simple protocol has been discovered that couples primary or secondary amines with N-aryl-substituted lactams to deliver differentiated diamines in moderate to high yields. The process allows for the partial reduction of a lactam in the presence of Cp2ZrHCl (Schwartz’s reagent), followed by a reductive amination between the resulting hemiaminal and primary or secondary amine. These reactions can be telescoped in a one-pot fashion to significantly simplify the operation. The scope of amines and substituted lactams of various ring sizes was demonstrated through the formation of a range of differentiated diamine products. Furthermore, this methodol. was expanded to include N-aryl pyrrolidinone substrates with an enantiopure ester group at the 5-position, and α-amino piperidinones were prepared with complete retention of stereochem. information. The development of this chem. has enabled the consideration of lactams as useful synthons.
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