Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, Synlett called Facile CuI-catalyzed arylation of azoles and amides using simple enaminones as efficient ligands, Author is Cheng, Cungui; Sun, Gonglei; Wan, Jieping; Sun, Cuirong, the main research direction is azole aryl halide arylation copper iodide dimethylaminopropenone hydroxyphenyl; arylated azole preparation; aryl halide amide arylation copper iodide dimethylaminopropenone hydroxyphenyl; amide arylated preparation; copper iodide arylation catalyst; dimethylaminopropenone hydroxyphenyl catalytic arylation ligand.Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one.
(E)-3-(Dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one was found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 °C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.
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