With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.1735, as common compound, the synthetic route is as follows.Quality Control of trans-4-Aminocyclohexanol
To a stirred mixture of (1 r,4r)-4-aminocyclohexanol (3.0 g) and DIPEA (5.0 mL) in DCM (100 mL) was added Boc2O (6.4 mL) slowly. The reaction mixture was stirred at RT for 3 hours. The mixture was concentrated under reduced pressure to give tert-butyl ((1 r,4r)-4- hydroxycyclohexyl)carbamate (5.7 g) as a pink solid. MS(ES) mlz 160 (M-t-Bu+H+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEN, Weichun; IGBOKO, Ebere F; LIN, Xichen; LU, Hongfu; REN, Feng; WREN, Paul Bryan; XU, Zhongmiao; YANG, Ting; ZHU, Lingdong; WO2015/181186; (2015); A1;,
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