In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Copper-catalyzed C-N coupling of amides and nitrogen-containing heterocycles in the presence of cesium fluoride, published in 2009-12-30, which mentions a compound: 7661-33-8, Name is 1-(4-Chlorophenyl)pyrrolidin-2-one, Molecular C10H10ClNO, Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.
The copper-catalyzed C-N coupling of amides to aryl halides usually requires the use of strong alkali metal bases, such as K2CO3, K3PO4, and Cs2CO3, at high temperature We discovered that CsF is sufficiently basic to promote the cross-coupling of amides and carbamates with aryl halides. Most aryl iodides coupled in high yield at room temperature This alternative base may be a suitable replacement for substrates that are incompatible with high temperature and strongly basic conditions and can further enhance the chemoselectivity of this reaction.
As far as I know, this compound(7661-33-8)Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
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