Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, European Journal of Organic Chemistry called Synthetic Exploration of α-Diazo γ-Butyrolactams, Author is Zhukovsky, Daniil; Dar’in, Dmitry; Kantin, Grigory; Krasavin, Mikhail, the main research direction is diazobutyrolactam pyrrolinone preparation; alc oxalylation hydride shift dimerization oxygen hydrogen insertion.Recommanded Product: 1-(4-Chlorophenyl)pyrrolidin-2-one.
Diazo transfer reaction onto γ-butyrolactams (activated by α-ethyloxalylation) gave rare α-diazo-γ-butyrolactams. Decomposition of the latter by Rh2(OAc)4 in the presence of alcs. and water gave products of O-H insertion of the resp. metal-cabene species. Silver triflate (1 mol%) was found to convert the investigated γ-butyrolactams into 1,5-dihydro-2H-pyrrol-2-ones which represent versatile building blocks. Particular instability was noted for α-diazo γ-butyrolactams bearing alkyl or o-substituted aryl substituents on the nitrogen atom. These were found to dimerize in solution or upon storage at room temperature to give fully conjugated bis-hydrazones along with the loss of a nitrogen mol.
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