Interesting scientific research on 16588-26-4

This literature about this compound(16588-26-4)Quality Control of 3-Bromo-4-chloronitrobenzenehas given us a lot of inspiration, and I hope that the research on this compound(3-Bromo-4-chloronitrobenzene) can be further advanced. Maybe we can get more compounds in a similar way.

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, European Journal of Organic Chemistry called Cobalt-Catalyzed C-N Bond-Forming Reaction between Chloronitrobenzenes and Secondary Amines, Author is Toma, Gabriel; Yamaguchi, Ryohei, which mentions a compound: 16588-26-4, SMILESS is BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl, Molecular C6H3BrClNO2, Quality Control of 3-Bromo-4-chloronitrobenzene.

Cyclic secondary amines react with mono- or dichloronitrobenzenes in the presence of a catalytic amount of cobalt(II) chloride. Phosphane ligands are beneficial for the reaction, although the bite-angle effect was not strong. The resulting nitro-substituted tertiary amines are important as bioactive compounds and can also be intermediates for the synthesis of substituted anilines. This work represents the first cobalt-catalyzed approach to C-N bond-forming reactions involving aromatic chlorides and cyclic secondary amines. The reaction is ortho- and para-selective, with meta-substituted halides being unreactive in this procedure.

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