Safety of 3-Bromo-4-chloronitrobenzene. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about GDC-0449-A potent inhibitor of the hedgehog pathway. [Erratum to document cited in CA151:550392]. Author is Robarge, Kirk D.; Brunton, Shirley A.; Castanedo, Georgette M.; Cui, Yong; Dina, Michael S.; Goldsmith, Richard; Gould, Stephen E.; Guichert, Oivin; Gunzner, Janet L.; Halladay, Jason; Jia, Wei; Khojasteh, Cyrus; Koehler, Michael F. T.; Kotkow, Karen; La, Hank; LaLonde, Rebecca L.; Lau, Kevin; Lee, Leslie; Marshall, Derek; Marsters, James C.; Murray, Lesley J.; Qian, Changgeng; Rubin, Lee L.; Salphati, Laurent; Stanley, Mark S.; Stibbard, John H. A.; Sutherlin, Daniel P.; Ubhayaker, Savita; Wang, Shumei; Wong, Susan; Xie, Minli.
On page 1, lines 59 -62 are incorrect; the correct versions of the lines are given. On page 5 lines 220-225 are incorrect; the correct versions of the lines are given. In addition, References 25, citing K Sasai et al., (2006) and 26, citing JT Romer et al., (2004), were erroneous omitted.
There is still a lot of research devoted to this compound(SMILES：BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl)Safety of 3-Bromo-4-chloronitrobenzene, and with the development of science, more effects of this compound(16588-26-4) can be discovered.
Reference:
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