In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photocytotoxic Pt(IV) complexes as prospective anticancer agents, published in 2019, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, Application In Synthesis of Dichloro(1,5-cyclooctadiene)platinum(II).
The use of Pt(IV) complexes as potential anticancer drugs is attractive, because they have higher stability and less side effects than Pt(II) compounds Moreover, some Pt(IV) complexes can also be activated with light, opening an avenue to photochemotherapy. Our purpose is to widen the library of photoactivatable Pt(II)-based prodrugs and here we report on the oxidation of the Pt(II) compound [PtCl(4′-phenyl-2,2′:6′,2”-terpyridine)][CF3SO3] (1) with PhICl2 or H2O2. The synthetic procedure avoids the formation of multiple species: the treatment with PhICl2 produces the Pt(IV) complex with axial chlorides, [PtCl3(4′-phenyl-2,2′:6′,2”-terpyridine)][CF3SO3] (2), while H2O2 oxidation and post-synthesis carboxylation produce [Pt(OCOCH3)2Cl(4′-phenyl-2,2′:6′,2”-terpyridine)][CF3SO3] (3), bearing acetates in the axial positions. 2 and 3 are stable in physiol.-like buffers and in DMSO in the dark, but undergo photoreduction to 1 upon irradiation at 365 nm. Their stability toward reduction is a fundamental parameter to consider: cyclic voltammetry experiments show that the 2 electron reduction Pt(IV) → Pt(II) occurs at a more neg. potential for 3, because of the greater stabilization provided by the acetate axial groups; noteworthily, 3 is stable for hours also in the presence of mM concentration of glutathione. The cytotoxicity of 2 and 3 toward A2780 and A2780cis cell lines reveals that 3 is the least toxic in the dark, but is able to produce cytotoxic effects far higher than cisplatin when irradiated. To shed light on the mechanistic aspects, the interaction with protein and DNA models has been explored through high-resolution mass spectrometry revealing that 2 and 3 behave as prodrugs, but are able to bind to biol. targets only after irradiation
There is still a lot of research devoted to this compound(SMILES：C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-])Application In Synthesis of Dichloro(1,5-cyclooctadiene)platinum(II), and with the development of science, more effects of this compound(12080-32-9) can be discovered.
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