The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate(SMILESS: CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12,cas:651780-02-8) is researched.HPLC of Formula: 3235-67-4. The article 《Scaffold oriented synthesis. Part 3: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:651780-02-8).
We report the synthesis and biol. evaluation of 5-substituted indazoles e. g., I and amino indazoles e. g., II as kinase inhibitors. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing [2+3] cycloaddition reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for numerous kinases such as Rock2, Gsk3β, Aurora2 and Jak2.
There is still a lot of research devoted to this compound(SMILES：CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12)HPLC of Formula: 651780-02-8, and with the development of science, more effects of this compound(651780-02-8) can be discovered.
Reference:
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