Related Products of 30379-58-9 ,Some common heterocyclic compound, 30379-58-9, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of lithium 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin- l-yl)ethyl)methylsulfonamido)benzoate (theoretical 0.869 mmol) and EDC (349 mg, 1.821 mmol) in dry DCM (3 ml), benzyl 2-hydroxyacetate (151 mg, 0.910 mmol) and DMAP (1 1 1 mg, 0.910 mmol) were added at RT. The final mixture was stirred for 2 days, then the solvent was evaporated, the residue was portioned between water and EtOAc, the organic layer was washed with NaHC03 sat. sol. and brine, dried over Na2S04 and evaporated. The crude was purified by flash chromatography on silica gel (eluent: DCM/MeOH/32%NH4OH 95/5/0.5) to give 2-(benzyloxy)-2- oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-l-yl)ethyl)- methylsulfonamido)benzoate as a colorless oil (370 mg, 0.661 mmol, 76% yield over 2 steps, MS/ESI+ 560.1 [MH] +).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30379-58-9, Benzyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria; WO2013/45280; (2013); A1;,
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