So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ghosh, Arun K.; Pandey, Satyendra; Gangarajula, Sudhakar; Kulkarni, Sarang; Xu, Xiaoming; Rao, Kalapala Venkateswara; Huang, Xiangping; Tang, Jordan researched the compound: 1-(2-Methylthiazol-4-yl)ethanone( cas:23002-78-0 ).Application of 23002-78-0.They published the article 《Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors》 about this compound( cas:23002-78-0 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: aminodihydroquinazoline preparation secretase inhibitor; quinazoline aminodihydro preparation secretase inhibitor. We’ll tell you more about this compound (cas:23002-78-0).
Structure-based design, synthesis, and biol. evaluation of a series of 2-amino-3,4-dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. One inhibitor showed potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays. The model of this compound suggested possible interactions in the active site.
If you want to learn more about this compound(1-(2-Methylthiazol-4-yl)ethanone)Application of 23002-78-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(23002-78-0).
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts